Pathogenetic relationship and ways of correction of H. pylori in patients with gastric and duodenal peptic ulcers in the combination of arterial hypertension and type 2 diabetes mellitus. Treatment of patient with H. pylori in presence of toxicogenic stra

Objective — to investigate the functional state of endothelium and methods correction endothelial dysfunction in patients with gastric duodenal peptic ulcers (GPU DPU) combination hypertension (AH) type 2 diabetes mellitus (DM2).
 Materials methods. The investigation involved 100 patients, who were divided into groups: group 1 consisted 20 apparently healthy individuals (AHI), included 40 GPU (n = 23) DPU 17) without signs AH DM2, 3 15) 25) DM2. groups sub‑divided subgroups A B depending on H. pylori strains’ toxigenicity: CagA+ VacA+ combination, infected a strains or VacA+. All administered traditional antihelicobacter therapy (AHBT) (esomeprazole mg twice daily + amoxicillin 1.0 g clarithromycin 500 for 10 days). To increase effectiveness eradication therapy, addition AHBT, received combined probiotic (Bifidobacterium bifidum, B. lactis, Enterococcusus acidophilus, L. paracasei, plantarum, rhamnosus, salivarius) sachet day month. Eradication control was monitored 4 weeks after completion treatment.
 Results. increased expression vascular cell adhesion molecule‑1 (VCAM‑1) number desquamated cells (DEK) improvement oxidant‑antioxidant system have been established. Before treatment, comparison levels AHI, sVCAM exceeded 5.88 times (р < 0.05), erythrocytic malondialdehyde 1.92 reduced glutathione lower by 46.39 % 0.05). use triple improved condition oxidative‑antioxidant system, additional application promoted more effective indices means maximal decrease levels.
 Conclusions. presence pylori, particular its toxigenic strains, results development disfunction DPU, arterial DM 2. When course is accompanied «mutual burden» syndrome resulting exhaustion antioxidant defense indexes system.